Currently, we offer one product: MUXF-HSA Proglycan CCD-blocker (PGB)
PGB-40 ... nominally 40 µg (10 % overfill allows use of actually 40 µg for a total of 2 mL of serum or serum dilution)
This is the standard size and it is shipped in boxes of 100 unless otherwise requested.
PGB-200 .... nominally 200 µg
Prices are set in a way that the cost of blocking CCDs is just a small fraction of the total cost of sIgE determination
Please place your inquiry or order HERE
The proglycan CCD-blocker is delivered as a freeze-dried powder that is stable for years.
The applicant will dissolve it in a specified volume of water.
The blocker is added to serum or serum dilution in a ratio of 1 to 50.
An IVDR conform Application Note is part of a shipment
Frequently asked questions --- or questions that should be asked.
What is the shelf life of the proglycan CCD-blocker once it is dissolved?
Once dissolved, either:
- store at 4°C (2-8°C) for up to 2 weeks
- store at -20 (below -15°C) for up to 6 months
When shall I add the blocker, before or after serum dilution?
Definitely, AFTER dilution. The effect of the blocker is concentration dependent. While there is a safety margin, a dilution of 1 : 4 or higher will almost certainly compromise the result.
Will readings always drop below the threshold?
A miniscule amount of antibody will always remain in solution. This can lead to values that (in rare cases) may be higher than the threshold for a positive result.
Can I achieve better blocking when using higher amounts of blocker?
In rare cases, yes. In cases where regular application failed to reduce readings below the positivity threshold, other factors may have to be considered. A typical example is that of bee and wasp venoms, where the non-culprit venom often remains slightly positive. This may well be caused by cross-reacting protein epitopes.
Can I save money by using lower amounts of blocker?
To some degree, yes. Strong signals may then, however, not be blocked efficiently. Weigh the cost savings against the cost of the test itself.
Can I substitute the blocker with natural glycoproteins?
Yes. Such glycoproteins may, however, contain peptide epitopes that cause unintended signal suppressions and false-negative results. Additionaly, most natural glycoproteins lack the polyvalency prerequisite for effective blocking.
Does the MUXF-HSA only adsorb IgE against MUXF but not the frequently occurring MMXF ?
Unless subtle difference will be shown by future research, the general view is that MMXF and MUXF as well as the insect typical structures MMF and MMFF* bind very similarly to IgE - regardless of the original sensitizing agent.
*(to be exact MUXF3, MMXF3, and MMF3 and MMF3F6)
Has the proglycan CCD-blocker been tried by others?
Yes, several notable manufacturers of allergy diagnosis systems offer the proglycan CCD-blocker as part of their product portfolio – albeit under their own name.
How can proglycan guarantee the safety and efficacy of their products?
We have implemented a quality management system in accordance with IVDR and are currently in the process of certification for ISO 13485.
All of our products have to pass through quality control. Every batch is carefully analysed with multiple methods to ensure proper loading with CCD structures to provide the multivalency pivotal for inhibitor efficacy.